Prevalence and risk factors of vitamin D deficiency in patients with widespread musculoskeletal pain
Muharrem Çidem 1 * , Seher Kara, Hakan Sarı, Murat Özkaya, İlhan Karaca
More Detail
1 Bağcılar Eğit. ve Araşt. Hastanesi Fizik Tedavi ve Rehabilitasyon Kliniği, İstanbul, Turkey* Corresponding Author


Objective: Vitamin D deficiency is a worldwide common health problems. Vitamin D deficiency in adults has been associated with proximal muscle weakness, skeletal mineralization defect, and an increased risk of falling. Patients with vitamin D deficiency commonly complain of widespread pain in the body. The aim of this study was to examine the prevalence and risk factors of 25-hydroxyvitamin D deficiency in patients complaining of widespread musculoskeletal pain.
Methods: In this cross-sectional study, 8457 patients with widespread musculoskeletal pain (7772 females, 685 males), aged 46.7 (range 20-100) years were included. Serum 25-hydroxyvitamin D was measured with ELISA method. Patients were classified into two groups: 1) Patients with vitamin D deficiency (<20 ng/ml) and 2). Patients without vitamin D deficiency ( >20 ng/ml).
Results: Prevalence of vitamin D deficiency was found to be 71.7%. A binary logistic regression model showed that low 25(OH)Vit D level was associated with gender, age and month in which 25(OH) hypovitaminosis was determined. The risk of low 25(OH) Vit D was found to be 2.15 times higher in female patients and 1.52 times higher on March and 1.55 times higher on April.
Conclusion: This study indicates that Vitamin D deficiency should be taken into consideration in patients with widespread musculoskeletal pain, and some precautions such as sunbathe during summer should be recommended patients having risk of vitamin D deficiency.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2013, Volume 4, Issue 4, 488-491

Publication date: 14 Dec 2013

Article Views: 2164

Article Downloads: 1523

Open Access References How to cite this article