Oxidative stress and its impacts on intracellular lipids, proteins and DNA
Oğuzhan Özcan 1 * , Hüseyin Erdal, Gökhan Çakırca, Zafer Yönden
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1 Mustafa Kemal Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya AD, Hatay, Turkey* Corresponding Author

Abstract

Oxidative stress is described as disturbed oxidative balance between increased reactive oxygen species such as hydroxyl radical (OH•), superoxide radical (O2−), hydrogen peroxide (H2O2) which occurs during normal cellular metabolism and decreased antioxidants which have scavenging effects on free radicals. Reactive oxygen species resulted from increased oxidative stress attacks on to the double bonds of lipids, proteins and DNA bases, removing one hydrogen atom from structure and initiate to oxidative chain reactions. This process leads to cellular damage and death damaging intracellular macromolecules such as lipids, proteins and DNA. The damage of free radicals is detected measuring oxidative products such as malondialdehyde (MDA), protein carbonyl (PCO) and 8-hydroxyguanine derivatives (8-OHG, 8-hidroksi-2′-deoksiguanozin) in body fluids and various tissues.
Although considerable amount of studies in this field, the effects of oxidative stress on cellular structures still remain unknown. In this review, we aimed to evaluate the biochemical aspects of oxidative stress, antioxidant systems and their mechanism of actions and oxidative products.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review

J Clin Exp Invest, 2015, Volume 6, Issue 3, 331-336

https://doi.org/10.5799/ahinjs.01.2015.03.0545

Publication date: 25 Oct 2015

Article Views: 3447

Article Downloads: 20065

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