Oxidative and antioxidative responses in submandibular and parotis glands of rats exposed to long-term extremely low frequency magnetic field
Mehmet Akdağ 1 * , Mehmet Zülküf Akdağ, Süleyman Daşdağ, Özcan Erel
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1 Dicle University Medical School, Department of Otolaryngology Diyarbakir, Turkey* Corresponding Author

Abstract

Background: Some epidemiologic and laboratory studies have suggested a possible associations between exposure to extremely low frequency magnetic field (ELF-MF) and cancer. However, it is not known underlying mechanisms of this interaction. The aim of the study was to investigate the possible oxidative damage induced by long-term ELF-MF exposure on submandibular and parotis glands of rats.
Methods: Rats in the experimental group were exposed to 100 and 500 µT ELF-MF (2 h/day, 7 days/week, for 10 months) corresponding to exposure levels that are considered safe for humans. The same experimental procedures were applied to the sham group, but the ELF generator was turned off. The levels of catalase (CAT), malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidative capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were measured in rat submandibular and parotis gland.
Results: Although some oxidative and antioxidative parameters of submandibular gland were altered by ELF-100 and ELF-500 exposure groups, these changes were not statistically significant ( p >0.05). However, a decrease observed in CAT levels of parotid gland in both the ELF-100 and ELF-500 exposure groups (p<0.05, p<0.01). No significant alterations was found in other endpoints related to parotid gland (p>0.05).
Conclusions: Our results showed that long-term ELF-MF exposure did not alter oxidative, antioxidative processes and lipid peroxidation in submandibular gland of rats. However, 100 µT and 500 µT ELF-MF exposure decreased CAT activity in parotid gland.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2014, Volume 5, Issue 2, 219-225

https://doi.org/10.5799/ahinjs.01.2014.02.0392

Publication date: 11 Jun 2014

Article Views: 1913

Article Downloads: 921

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