Myrtus Communis (Myrtle Tree: leaf and body) extract in Rat Renal Ischemia/Reperfusion injury
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Hazen Saritas 1 * , Hasan Huseyin Demirel 2 , Aziz Bulbul 3 , Fatma Gorucu 4 , Zeynep Uğurlu 5 , Yusuf Koc 4 , Ibrahim Demirkan 4 , Zulfukar Kadir Saritas 4
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1 Aksaray University, Faculty of Medicine, Department of Nephrology, Aksaray, Turkey2 Afyon Kocatepe University, Bayat Laborant and Veterinary Health Division, Afyonkarahisar, Turkey3 Mugla Sitki Kocman University, Milas Veterinary Faculty, Department of Physiology, Mugla, Turkey4 Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Surgery, Afyon, Turkey5 Ars Arthro Biotechnology A.Ş., Senior Researcher, Ankara, Turkey* Corresponding Author

Abstract

Aim: The aim of this study was to investigate the protective effect of myrtus communis extract (MCE) against renal I/R injury.
Materials and methods: 36 adult males Wistar albino rats, weighing 250-300 g, were divided into six groups of six rats each. Group 1 was designated as the sham group. Group 2 was designated as the control one. MCE was administered via gastric gavage over a period of 10 days, dosed at 0.1 mL/kg/day in the third group, 0.2 mL/kg/day in the fourth group, 0.3 mL/kg/day in the fifth group, and 0.5 mL/kg/day in the sixth group. On the 10th day, the I/R procedure was performed.
Results: The pathological examination showed that the formation of hyaline cylinders in the tubular lumen was significantly higher in the control group when compared to the others (p<0.05). Glomerular Bowman space enlargement was statistically significantly lower in groups 5 and 6 compared with the controls (p<0.05). The levels of tumor necrosis factor-alpha (TNF-α), interleukin 1-beta (IL-1β), IL-6, matrix metalloproteinase-8 (MMP-8), hydroxyproline, myeloperoxidase (MPO), and total oxidant status (TOS) were found to be increased in the control group when compared with the others (p<0.05), while a statistically significant reduction was seen in the levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) (p<0.05).
Conclusions: MCE protected kidney tissue against I/R injury. This result was most likely due to the antioxidant properties of MCE. MCE is a promising natural substance for preventing I/R damage.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J CLIN EXP INVEST, 2022, Volume 13, Issue 4, Article No: em00807

https://doi.org/10.29333/jcei/12410

Publication date: 29 Aug 2022

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