Multipl skleroz hastalarında otonom sinir sistemi ile ilişkili sempatik cilt yanıtlarının değerlendirilmesi ve yorgunluk skorları [Sympathetic skin responses associated with the autonomic nervous system and fatigue scores in patients with MS]
Şeyda Bayil Yetik, Emine Rabia Koç 1 * , Ali Kemal Erdemoğlu
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1 Fatih Üniversitesi Tıp Fakültesi Nöroloji AD. İstanbul, Turkey
* Corresponding Author


Objectives: In this study, we aimed to investigate the effect of autonomic dysfunction on quality of life and symptoms of fatigue patients with MS.
Materials and methods: The study included 30 patients with MS and 35 healthy subjects as control group. Disability was assessed using the Expanded Disability Status Scale (EDSS); autonomic functions were assessed by SSR; fatigue symptoms were assessed by Fatigue Descriptive Scale (FDS); effect of autonomic dysfunction on quality of life and fatigue symptoms was assessed by SF-36 scale.
Results: There was no significant difference between the left hand SSR latency, mean amplitude and area between patient and control groups. Mean FDS value was significantly higher in MS group. SSR amplitude and area were significantly smaller in patients which received prophylactic treatment. There was no relation between the FDS scores and SSR values in patients receiving prophylaxis. In the patient group, a positive correlation was detected between EDSS and FDS score; and significantly negative correlation between pyramidal, cerebellar and spasticity; a significant positive correlation was found between amplitude and the size of area of the SSR and brain stem functions. There was no significant relationship between FDS with SSR area, latency and amplitude.
Conclusions: SSR measurements are not sensitive in order to evaluate autonomic dysfunction in patients with multiple sclerosis. Symptoms of fatigue has a negatively effect on the activity of the patient's daily life. SSR test is not sufficient to show the relationship between fatigue and autonomic dysfunction.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2012 - Volume 3 Issue 3, pp. 387-391

Publication date: 11 Sep 2012

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Article Downloads: 533

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