Mortality and morbidity analysis in neonates supported by invasive mechanical ventilation

J Clin Exp Invest 2012;3(4):483-492.


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Objectives: To evaluate mortality, morbidity, and invasive mechanical ventilation complications in mechanically ventilated neonates in a tertiary care hospital, Istanbul, Turkey.
Materials and methods: The neonates followed on invasive mechanical ventilation from January 2008 to December 2009 were included in the study. A chart is formed for each patient to record patient delivery room and clinical data prospectively.
Results: The study population consisted of 236 neonates. Eighty-five percent were born at ≤37 completed weeks of gestation (n=201). Fifty-two percent (n=123) were males. The mean gestational age was 31.9±5 weeks. The mean birthweight was 1870.8±921.8 g. Antenatal steroid rate was 13.3% (n=20) in 150 cases born at ≤34 weeks of gestation. Respiratory distress syndrome (n=100, 42,3%), perinatal depression and asphyxia (n=51, 21,6%), and sepsis (n=47, 19.9%) were the commonest indications. Mechanical ventilation related complications (nosocomial infection (n=57), pulmonary hemorrhage (n=30), pneumonia (n=10), pneumothorax (n=9), and atelectasis (n=4)) developed in 33.5% of neonates (n=79). Bronchopulmonary dysplasia was 9.3%, intracranial hemorrhage (≥grade 3) 8.47%, periventricular leukomalacia 5.93%, necrotizing enterocolitis (>stage 2) 0.42%, and retinopathy of prematurity (>stage 2) 2.96%. Mortality rate was 30.17%. Neonates born at <28 weeks of gestation and with birthweight ≤1000 gram had statistically higher mortality rate than the neonates born at ≥28 weeks of gestation and with birth weight >1000 gram (p<0.05, p<0.05, respectively).
Conclusions: Low birthweight and low gestational age are important risk factors for neonatal mortality and morbidity. Low frequency of antenatal steroid use may be a contributing factor to increase neonatal mortality and morbidity.


Neonate, invasive mechanical ventilation, mortality, morbidity


Kılıç A, Salihoğlu Ö, Tan İ, Akyol B, Hatipoğlu SS. Mortality and morbidity analysis in neonates supported by invasive mechanical ventilation. J Clin Exp Invest. 2012;3(4):483-92.