Mortality and morbidity analysis in neonates supported by invasive mechanical ventilation
Azer Kılıç, Özgül Salihoğlu 1 * , İlhan Tan, Bedir Akyol, Sadık Sami Hatipoğlu
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1 Bakırköy Dr. Sadi Konuk EAH, İstanbul, Turkey* Corresponding Author


Objectives: To evaluate mortality, morbidity, and invasive mechanical ventilation complications in mechanically ventilated neonates in a tertiary care hospital, Istanbul, Turkey.
Materials and methods: The neonates followed on invasive mechanical ventilation from January 2008 to December 2009 were included in the study. A chart is formed for each patient to record patient delivery room and clinical data prospectively.
Results: The study population consisted of 236 neonates. Eighty-five percent were born at ≤37 completed weeks of gestation (n=201). Fifty-two percent (n=123) were males. The mean gestational age was 31.9±5 weeks. The mean birthweight was 1870.8±921.8 g. Antenatal steroid rate was 13.3% (n=20) in 150 cases born at ≤34 weeks of gestation. Respiratory distress syndrome (n=100, 42,3%), perinatal depression and asphyxia (n=51, 21,6%), and sepsis (n=47, 19.9%) were the commonest indications. Mechanical ventilation related complications (nosocomial infection (n=57), pulmonary hemorrhage (n=30), pneumonia (n=10), pneumothorax (n=9), and atelectasis (n=4)) developed in 33.5% of neonates (n=79). Bronchopulmonary dysplasia was 9.3%, intracranial hemorrhage (≥grade 3) 8.47%, periventricular leukomalacia 5.93%, necrotizing enterocolitis (>stage 2) 0.42%, and retinopathy of prematurity (>stage 2) 2.96%. Mortality rate was 30.17%. Neonates born at <28 weeks of gestation and with birthweight ≤1000 gram had statistically higher mortality rate than the neonates born at ≥28 weeks of gestation and with birth weight >1000 gram (p<0.05, p<0.05, respectively).
Conclusions: Low birthweight and low gestational age are important risk factors for neonatal mortality and morbidity. Low frequency of antenatal steroid use may be a contributing factor to increase neonatal mortality and morbidity.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2012, Volume 3, Issue 4, 483-492

Publication date: 13 Dec 2012

Article Views: 2403

Article Downloads: 1296

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