Ischemia Modified Albumin as a Novel Biochemical Indicator in Peripheral Artery Patients
Mustafa Etli 1 , Hasan Basri Savas 2 *
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1 Alanya Alaaddin Keykubat University, Faculty of Medicine, Department of Cardiovascular Surgery, Alanya, Antalya, Turkey2 Alanya Alaaddin Keykubat University, Faculty of Medicine, Department of Medical Biochemistry, Antalya, Turkey* Corresponding Author


Objective: Peripheral artery disease (PAD) is the name given to blocked blood flow in major arteries other than cerebral and coronary circulation. The diagnosis and treatment of PAD is very important because of the high frequency of PAD. In this study, it was aimed to investigate the possible change in next generation oxidative stress-antioxidant status indicators as a biochemical parameter that may be useful in the diagnosis and follow-up of PAD.
Method: Forty healthy controls and 40 male and female patients with peripheral artery disease who applied to the Alanya Alaaddin Keykubat University Research and Training Hospital were enrolled in the study on a voluntary basis. Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), ischemia modified albumin (IMA) and Thiol balance were studied with the colorimetric method.
Results: The TOS (p <0.001), OSI (p <0.001), IMA (p = 0.027), total thiol (0.004) levels were higher in the peripheral artery patients compared to the control group, while the TAS (p <0.001) and native thiol / total thiol ratio (index 3) (p = 0.018) values ​​were significantly lower.
Conclusion: The increase in TOS and IMA levels may be used as an indicator of peripheral artery disease. There is an increase in inflammation in the ischemia and atherosclerosis processes. An ischemia-specific protein called ischemia-modified albumin may be used as a rapid and practical laboratory marker in common peripheral artery disease.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J CLIN EXP INVEST, 2021, Volume 12, Issue 3, Article No: em00774

Publication date: 28 May 2021

Article Views: 1489

Article Downloads: 719

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