Influence of sevoflurane on hemodynamic parameters in low flow anesthesia applied without nitrous oxide
Özer Debre, Aykut Sarıtaş 1 * , Yılmaz Şentürk
More Detail
1 Prof.Dr. A. İlhan Özdemir Public Hospital Giresun, Turkey* Corresponding Author


Objective: In this study, it was aimed to investigate the hemodynamic effects of sevoflurane in low flow anesthesia (LFA) without nitrous oxide.
Methods: A total of 40 ASA I-II patients aged between 18-70 years were included in this study. Patients were randomly allocated to two groups. Group 1 (LFA with nitrous oxide) was applied preoxygenation with 10 L/min 100% Ofor 2 min. After preoxygenation, 4-7 mg/kg pentothal, 0.1 mg/kg vecuronium bromide and 1 μg/kg fentanyl were applied respectively via intravenous route. Endotracheal intubation was applied 3 min later after induction. 4 L/min (50% O2-50% N2O) normal flow had been applied within the first 10 min of the operation following intubation, it was switched to 1 L/min (50% O2-50% N2O) low flow. Sevoflurane concentration was set as 0.8-1 MAK so as to keep mean blood pressure (MBP) within ± 20% limits. In Group 2 (LFA without nitrous oxide) all procedure was the same with Group I except that air was used instead of N2O. Heart rate (HR), MAP, SPO2 and ETCO2 values were recorded just after intubation and following 15, 30, 45 and 60. min and switched to 4 L/min of normal flow 15 min before termination of the operation.
Results: There were no significant differences between the groups from measurement after induction to 60 min measurement in terms of systolic blood pressure (SBP) and ETCO2. Values in Group I were found greater than those in Group II at 15 min measurement in terms of diastolic blood pressure (DBP), MAP and HR (p<0,05). No complications were encountered in patients.
Conclusion: We concluded that preferring LFA techniques applied without N2O, with sevoflurane is beneficial if proper conditions are provided


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, Volume 5, Issue 1, March 2014, 12-17

Publication date: 11 Mar 2014

Article Views: 2392

Article Downloads: 909

Open Access References How to cite this article