First trimester serum PAPP-A levels and the prediction of small-for-gestational age infants
Nilgün Güdücü 1 * , Gökçenur Gönenç, Herman İşçi, Alin Başgül Yiğiter, İlkkan Dünder
More Detail
1 İstanbul Bilim University, Europe Hospital, Department of Obstetrics and Gynecology, İstanbul, Turkey* Corresponding Author


Objectives: The aim of this study was to detect the predictive value of PAPP-A in small-for-gestational age (SGA) infants.
Materials and methods: We retrospectively searched the patient charts of our hospital for first trimester Down syndrome screening test results. PAPP-A levels less than 5th percentile were considered as predictive of SGA infants.
Results: Low PAPP-A levels were associated with SGA infants, sensitivity was 3,5%, specificity 90%, positive predictive value 1,6% and negative predictive value 95%.
Conclusions: The low positive predictive value of PAPP-A prevents it from being used as a screening test for the detection of SGA infants.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2012, Volume 3, Issue 2, 185-188

Publication date: 12 Jun 2012

Article Views: 3155

Article Downloads: 929

Open Access References How to cite this article