Comparing efficacy of preemptively used dexketoprofen and tramadol for postoperative pain in patients underwent laparoscopic cholecystectomy
Süreyya Özkan 1 * , Belgin Yavaşcaoğlu, Fatma Nur Kaya, Berrin Özcan, Selcan Bayraktar, İrem Başeğmez, Şule Yazıcı
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1 Uludağ Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD Görükle, Bursa, Turkey
* Corresponding Author


Objective: In our study, we aimed to compare effects of preoperative dexketoprofen and tramadol administered by intravenous route on intraoperative and postoperative analgesic consumption, postoperative pain, durations of hospital stay and patient satisfaction in patients, undergoing laparoscopic cholecystectomy.
Methods: After approval of ethic committee and written consent of patients were obtained, 60 patients between 18-70 years old with ASA I-II were included in the study. After routine monitorization and 20 minutes before induction of anesthesia, dexketoprofen 50 mg in 100 cc 0.9% NaCl was administered in Dexketoprofen Group and tramadol 100 mg in 100 cc 0.9% NaCl in Tramadol Group as intravenous infusion during 20 minutes. Intraoperative hemodynamic parameters, analgesic-anesthetic consumptions and complications of patients, on whom standard general anesthesia was applied, were recorded. Pain severity, degree of sedation, morphine consumptions and hemodynamic parameters were recorded at postoperative 30th minute, and 4th, 8th, 12th and 24th hours. Additional analgesia requirement,
times for requiring first analgesia, duration of hospital stay, postoperative complications and patient satisfactions were recorded.
Results: Intraoperative analgesic-anesthetic consumptions, postoperative visual analogue scale (VAS) scores, sedation degrees, intravenous patient controlled analgesia (PCA) and morphine consumptions, times for requiring first analgesic, durations of hospital stay, intraoperative-postoperative complications developed and patient satisfactions were similar in both groups. Consequently, postoperative analgesic efficacy of pre-emptive dexketoprofen intravenous 50 mg and tramadol intravenous 100 mg administered was found to be similar in cases, who had laparoscopic cholecystectomy operation.
Conclusion: Because VAS scores were low in our patients, morphine consumptions with intravenous PCA were similar in both groups, and there wasn’t any additional analgesic requirement in our patients, we think that use of both tramadol and dexketoprofen for preemptive analgesia would be useful. 


This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2015 - Volume 6 Issue 1, pp. 44-51

Publication date: 10 May 2015

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Article Downloads: 694

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