Cleidocranial dysplasia: Etiology, clinicoradiological presentation and management
İsmet Rezani Toptancı 1 * , Hakan Çolak, Serhat Köseoğlu
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1 Dicle University, Dental Faculty, Department of Pedodontics, Diyarbakır, Turkey* Corresponding Author

Abstract

Cleidocranial dysplasia (CCD) is an autosomal dominant skeletal dysplasia characterised by abnormal clavicles, patent sutures and fontanelles, supernumerary teeth, short stature, and a variety of other skeletal change. Cleidocranial dysplasia is caused by mutation in the gene on 6p21 encoding transcription factor CBFA1, i.e. runt-related transcription factor 2 (RUNX2). Individuals with CCD should be followed by either a team of specialist or by individual specialist familiar with the problems that can be associated with this condition.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review

J Clin Exp Invest, Volume 3, Issue 1, March 2012, 133-136

https://doi.org/10.5799/ahinjs.01.2012.01.0131

Publication date: 13 Mar 2012

Article Views: 2776

Article Downloads: 2088

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