Cervical adenoid basal carcinoma: Case report
Ulaş Alabalık 1 * , Uğur Fırat, Ayşe Nur Keleş, Gül Türkcü, Zuhat Urakçı, Elif Ağaçayak
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1 Dicle Üniversitesi Tıp Fakültesi Patoloji AD, Diyarbakır, Turkey
* Corresponding Author

Abstract

Adenoid basal carcinomas are rare tumors that accounts for less than 1% of all cervical cancers. Generally they are seen in postmenopausal women. Macroscopically these tumors do not reach large sizes. Microscopically adenoid basal carcinomas are composed of uniform, round, basaloid cells that form nests surrounded by palisade formations. These tumors express CAM 5.2, CK7, EMA, and CEA immunohistochemically. In evaluation of the material referred to our unit, an ulcerated mass lesion that is located on uterine posterior wall is determined. On microscopic examination of sections prepared from the mass, under the surface epithelium accompanied by severe dysplasia, a tumoral formation composed of basaloid cells is observed. It is seen that the tumor demonstrate configurations of nests and islets which comprise generally peripheral palisading. When the tumoral cells are characterized by mild to moderate pleomorphism and atypia, the mitotic index is detected low. In immunohistochemical studies, the tumoral cells are positively stained with CEA and CK7, and negatively stained with HMWCK, vimentin, CD34, and HPV18. Adenoid basal carcinoma cases typically do not manifest with local recurrence or metastasis and have very good prognosis. Our case has filled 48 months after the diagnosis and any local recurrence or metastasis has not been observed.

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

https://doi.org/10.5799/ahinjs.01.2014.04.0470

J Clin Exp Invest, 2014 - Volume 5 Issue 4, pp. 614-616

Publication date: 10 Dec 2014

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Article Downloads: 563

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