Benign Endometrial Polyp and Primary Endometrial Small Cell Neuroendocrine Carcinoma Confined to the Polyp: A Rare Association
Pembe Oltulu 1 * , Ceyhan Uğurluoğlu, Ayşenur Uğur, Sıdıka Fındık, Lema Tavlı
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1 Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi, Patoloji AD. Konya, Turkey* Corresponding Author

Abstract

Neuroendocrine tumors (NETs) are a heterogeneous group of tumoral lesions originating from diffuse endo­crine system cells. They occur mostly in the gastrointes­tinal system and the lung. Primary NETs of the female reproductive tract are rare. In a widely used classification, primary small cell neuroendocrine carcinomas (SCNECs) and large cell neuroendocrine carcinomas (LCNECs) of the endometrium were included in a subgroup of poorly differentiated neuroendocrine carcinomas. SCNECs of the endometrium are very rare and they are often com­bined with other epithelial neoplasms. Their myometrial and extrauterine invasions are common during the initial diagnosis due to their aggressive behaviors. In this ar­ticle, we present a rare case of primary endometrial SC­NEC detected within the benign endometrial polyp and without invasion of myometrium and extrauterine tissues in a 70-year-old female patient presenting with post­menopausal bleeding. Histopathologically, the tumor cells showed positive staining with Synaptophysin, the Ki-67 labeling index was 80-90%, the mitotic index was 15/10 per HPF and there was no necrosis and lymphovascular invasion.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

J Clin Exp Invest, 2016, Volume 7, Issue 1, 107-110

https://doi.org/10.5799/jcei.328701

Publication date: 01 Mar 2016

Article Views: 1778

Article Downloads: 1324

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