Anticoagulant Therapy in Primary and Secondary Recurrent Pregnancy Losses with Hereditary Thrombophilia and Perinatal Outcomes
Hatice Işık 1 * , Hüsnü Alptekin, Refika Selimoğlu, Türkan Cengiz, Hasibe Uygun Kucukapan, Nazife Alptekin
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1 Mevlana University Faculty of Medicine, Department of Obstetrics and Gynecology, Konya, Turkey* Corresponding Author


Objective: To investigate the effect of anticoagulant treat­ment and perinatal outcomes in patients with primary or secondary recurrent pregnancy loss without cause other than inherited trombophilia.
Methods: A total of 143 pregnant patients with recurrent pregnancy loss (≥2 abortus) and had no detected cause other than thrombophilia, were included in the study. Pa­tients with no livebirth history were accepted as primary and patients with at least one livebirth were as second­ary recurrent spontaneous aborters (PrimRSAs and Se­cRSAs). Inherited thrombophilia genetic results of the patients in both groups were compared. The effects of low-molecular weight heparin (LMWH) and low-dose as­pirin (LDA) treatments alone or together, livebirth rates and pregnancy outcomes were investigated.
Results: Sixty-eight patients were in PrimRSAs and 75 were in SecRSAs. Ages, numbers of total, early and late pregnancy loss of both groups were similar. In PrimRSAs 49 (72.1%) and in SecRSAs 50 (66.6%) patients had three or more inherited thrombophilia genetic mutations. Of 113 patients who used LMWH+LDA during pregnancy 88 (77.6%) had livebirth; however, of 19 patients who used LMWH 6 (31.6%) and of 11 women who used LDA 8 (72.7%) had livebirth. Livebirth rate was significantly high­er in patients who used LMWH+LDA together (p=0.001). Livebirth rates were higher in SecRSAs than PrimRSAs irrespective to the anticoagulant treatment (p=0.002).
Conclusion: LMWH and LDA treatment together may in­crease livebirth rates in patients with recurrent pregnancy loss and inherited thrombophilia. Having at least one live­birth of the patients is a good prognostic factor.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Research Article

J Clin Exp Invest, 2016, Volume 7, Issue 1, 29-34

Publication date: 01 Mar 2016

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Article Downloads: 1349

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